I think a 100k VR is overkill for vcore. I used 2 25K pot's. If you go too high (~2.1v) the board will shut down, so you're OK provided you have good cooling. Actually mine overvolts a bit under load so I can only go to a max of 2.00v idle, which gives around 2.08v under load.

To answer your original question, yes, set it to the maximum resistance (100K).