Loadline Calibration Shouldn't damge anything, all it will do is stop vdroop meaning that your CPU when on full load the voltage shouldn't drop and when idle the voltage always stays the same, it shouldn't harm anything, I have had it on from day 1, Only thing that could damage something is clocking your PCI-E port in the bios which can damage your GPU and also the motherboard. but part from that Loadline Calibration is just a pencil mod but without the hardwork