Raz,
such a harsh effect looks extremely unusual. 25 MHz are nothing for a 45 nm quadcore. I've had a Maximus Formula board and now the P5Q3, so I can roughly say about your P5E3 that this should not happen. And by now it looks to me that this is a general reaction of intel systems that run DDR3 RAM. My P45 is a dieshrink compared to your X38, yet, it seems so familar.
This really looks more like an issue of Prime 95, frankly.
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