One thing I noticed as I started to overclock is that the northbridge is HOT!
Even at only 300fsb x 8 with the e6400 and 30 minutes of priming, it's very warm, the entire heatsink is.
I'm using one of these coolermaster sinks on there with AS5.. the entire aluminum portion of the sink is quite warm, at least I know the sink is doing it's job well... northbridge temp reads 42 degrees after 20 minutes of priming and seems to stablize there at 300fsb at least... now at 325.
http://www.xoxide.com/cooler-master-blue-ice-2.html
I shudder at the idea of what that poor northbridge is going through for those using the stock heatsink, even with a fan, trying to push that fsb above 450 with it. Even the southbridge is warm enough where I may consider replacing it with something else.