Nvidia driver + Windows 10 multi-monitor positioning problem

[Mechromancer]

Windows 10 changes my screen position to an unusable state and I cannot reset it. I have two displays. If I open a game, change my resolution, or change the refresh rate of my monitors the #1 display will move to the lower right corner of my #2 display. I cannot move it back. The screen moves back to that position after I hit apply. I've reinstalled the driver multiple times and edited the registry. This problem continuously reoccurs.

If I can't solve this, I'm going to wipe my system and start all over.

Thanks for any help in advance!

[BenchZowner]

Try to delete all the monitor profiles in registry.
Restart the PC with 1 monitor ( the intended main ) hooked up, then connect the second monitor, arrange them and configure them and see if you are good to go or still facing the same problem.

[Mechromancer]

Deleting the registry entries did not work. I actually have to do that every time it does this to get the configuration set right again. The moment I launch a game or make a display change, it messes up again. I just refreshed Windows 10 and kept my files and apps. I also rolled the driver back from 390.77 to 375. Nothing is working so I think I have to completely nuke my installation.

It pains me to say that but I have to bite the bullet on this one.

Thanks for your help!

[kromosto]

Does it come back to its original location when you exit from the game? Do your monitors have the same resolution? Do you use different scale values for your monitors? I have a similar problem that if I don't use the natural resolution of my monitor on a game it moves other windows to right and they go outside the visible area.