Here is a place for us discuss all things Borderlands 2 now that it has launched.
Geforce.com has their Borderlands 2 Tweak Guide by Koroush Ghazi.
Bl2wiki and borderlandswikia both have some decent info although they both need time and user effort to grow.
Being a steamworks title, Borderlands 2 requires access to ports 3478,4379-4380,27000-27050. You shouldn't have to touch anything but many software firewills will interfere and pending your networking hardwares configuration, some forwarding may be required. That said I've had no such issues myself both using Comodo and an Asus RTN66U.
Feel free to post your experiance with the game, any tweaks, tips and please give a shout out if you are looking to find someone to play with I personally spent a considerable amount of time with the first game and this one is certainly not going to buck that trend
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