The aquabus is AFAIK based on I2C and can be daisy chained.
On a previous build I had two aquastreams, a multiswitch and an AE4 linked by aquabus, but there was really little practical use for it except flashing the control circuitry on the pumps, the configuration possibilities via aquabus were very limited. The real flexibility was achieved via USB (I ended up putting a USB hub inside the computer to have enough ports for everything as I also had a poweradjust and a number of other devices...)
Of course with the AE5 this may change, and the aquabus may become more useful
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