Fugger is correct. The internal water inlet is dead center in the reservoir so from an internal geometry stand point there is really no performance difference between horizontal and vertical mounting. He is also correct on the fill/bleed ports so you will want to leave enough play in your tubing to rotate the reservoir 90 degrees for filling and bleeding air. The normal give in most loops is generally enough for this.
One other item to keep in mind. I would recommend mounting the reservoir so that the rear inlet ports are on the bottom to avoid any possible splashing sound. Think of one of those back yard kiddy pools and filling it with a garden hose--if you hold the hose a few feet above the pool you hear the water splashing. If you hold the garden hose under the water in the pool it is silent. Goofy analogy I know, sorry. The instruction manual identifies the rear ports for you.
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