Well according to eVGA if you have more than 4 cards in the PCIe slots, then it will change all of them to x8 (as compared to Gigabyte's spec sheet which show 4x16 AND 3x8). So for example if I had 3 GTX 480s and a SSD PCIe and then put in a PCIe sound card, it would drop the GPUs and SSD from x16 to x8, which would impact performance.
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