I'm pretty sure it will be ok, IIRC I used it on a cpu to remove a pin mod I did using conductive silver (cpu was an e6300) and nothing happened to the cpu. It wont melt through it immediately or anything, just wipe a cotton bud on it and see if anything comes off on the cotton or if it discolours the cpu substrate. The CPU substrate may be different composition to ram/PCB of gfx card I'd test it on the top corner of the cpu itself. It's difficult to suggest an appropriate solvent, as the epoxy/resin the IHS is held on with is similar to the composition of the cpu substrate. What dissolves one will most likely damage the other. Mechanically separating it with a blade is definitely safer.
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