Hard to say just give it a try and see what happens. Use only 1 dimm, that might help. And yes after cmos clear vdimm wil be back to default. I use XMS2 rated 2.1v and had trouble getting it up and running but not sure if it was the ram itself or the fact me board wil not run at anything under 401 FSB. I ended up using a no name dimm to set vdimm though.